American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Archives of General Psychiatry, Behavioral Brain Research, Biological Psychiatry, Brain Research, European Journal of Neurology, European Journal of Neuroscience, European Neuropsychopharmacology, International Journal of Neuropsychopharmacology, Journal of Affective Disorders, Journal of Clinical Psychiatry, Journal of Neural Transmission, Journal of Neuroscience Research, Journal of Psychiatric Research, Journal of Psychopharmacology, Molecular Psychiatry, Neuropharmacology, Neuroscience, Neuroscience Letters, Psychoneuroendocrinology, Psychopharmacology
Deutsche Forschungsgemeinschaft (DFG), Israel Science Foundation; National Science Foundation, USA; Chief Scientist Office Biomedical and Therapeutic Research Committee, Scotland; TV3 Marató Foundation, Barcelona, Spain.
Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP)
Collegium Internationale Neuropsychopharmacologicum (CINP)
Deutsche Gesellschaft für Bipolare Störungen (DGBS)
Deutsche Gesellschaft für Psychiatrie, Psychiatrie und Psychotherapie (DGPPN), Board member “Genetics and Neurobiology”
Deutsche Gesellschaft für Biologische Psychiatrie (DGBP)
European College of Neuropsychopharmacology (ECNP)
International Society of Psychiatric Genetics (ISPG)
World Federation of ADHD
1) Principle Investigator, German Research Foundation, Grant # RE1632/1-1, 1-2 and 1-3, "Investigations on the pathogenetic involvement of nitrinergic signaling in schizophrenic psychoses", 01/2003 – 12/2008
The major aims of this project was to elucidate whether NOS1 is associated with schizophrenia or bipolar disorder; whether there are histopathological abnormalities in NOS-I positive neurons in schizophrenia; and to elucidate the role of NOS in adult neurogenesis. There were positive findings concerning all questions.
2) Principle Investigator, German Ministry of Education and Research (IZKF Würzburg, N-27-N: High throughput genotyping of glutamatergic candidate genes in schizophrenic disorders) 2007 – 2009
The primary aim of the project was to establish a high-throughput genotyping method (Sequenom MALDI-TOF system), which has been accomplished. The secondary aim was to investigate test for an association of glutamatergic candidate genes with schizophrenia. Several genes were identified and also linked with endophenotypes such as working memory and fNIRS.
3) Principle Investigator within a Clinical Research Group, Grant # KFO 125/1-1 and 1-2TP D (Attention deficit / hyperactivity syndrome: molecular pathogenesis and endophenotypes during the course of therapy; subproject D: Behavioral phenotyping of transgenic animals with respect to ADHS) 2004 – 2010
The primary aim was to establish a behavioral phenotyping unit for knockout mice with special emphasis on learning and attention (accomplished). Thereafter, animal models for ADHD were developed and evaluated especially considering gene x environment interactions. Specifically, Tph2 and M1 knockout mice were extensively tested.
4) Principle Investigator within a Collaborative Research Centre, Grant # TRR58-Z2 (Fear, Anxiety, Anxiety disorders; subproject Z2: Functional genomics and gene-environment interactions in dimensional endophenotypes of fear and anxiety) 2008 – 2012
The primary aim is to ascertain a large cohort of healthy volunteers (1,500 subjects) who are well characterized with respect to anxiety-relevant personality traits and life history. Those subjects will be stratified for candidate gene polymorphisms and channeled in endophenotype experiments (neuropsychology, imaging). Furthermore, the whole cohort will be subjected to a GWAS with respect to a proxy measure for anxiety (ASI questionnaire).
5) Co-Principle Investigator, Research grant of the DFG, Grant No. DE357/4-1: „Relevance of initial panic attacks fort he pathogenesis of panic disorder“, 2009 – 2012. The aim is to identify risk genes which predispose for the transition from syndromal panic attacks to panic disorder in a large, well characterized population based sample.
6) Co-Principle Investigator, Research grant of the German Ministry of Education, Science, Research and Technology within the psychotherapy network „Panic-net“; subproject P6: „Mechanisms of fear reduction in panic disorder: The role of genetic variation“, 2009 – 2011. This is a genetic sub-study of a large multicenter treatment study in panic disorder, where we investigate for risk genes of panic disorder as well as their impact on treatment response.
7) Principle Investigator, Research grant of the DFG, Grant no. RE 1632/5: „Functional psychobiology of a regulatory NO synthase polymorphism“, 2010 – 2013. The molecular consequences of a promoter polymorphism in the NOS1 gene, which is associated with impulsive behaviors, are examined.