Dr. med. Andreas Menke

Andreas Menke, M.D.
Department of Psychiatry, Psychosomatics and Psychotherapy
Margarete-Hoeppel-Platz 1 
D-97080 Wuerzburg, Germany

e-mail: Menke_A@ukw.de
twitter: @Dr_A_Me
Tel.: 0931-201-76050; Fax: 0931-201-6076343

Postgraduate Training and Employment:

2018-present Senior Consultant at the Department of Psychiatry, Psychosomatics and Psychotherapy
Head of Research Group „Personalized Therapy of Affective Disorders“
University Hospital of Wuerzburg, Germany


2005 Thesis, rated at the Ruprecht-Karls University of Heidelberg with „magna cum laude”
1997–2004 Medical school at the Ruprecht-Karls University Heidelberg

Clinical focus:

Mood disorders (major depression and bipolar disorder), stress-associated disorders

Research focus:

Neuroendocrinology, molecular genetics (induced mRNA expression in peripheral blood, genetic markers), biomarker, personalized medicine.


  • Depression associated cardiac failure (DACFAIL), BMBF/DLR
  • Determining the reciprocal relationship between heart failure and brain function, BMBF/DLR
  • Cerebral serotonin transporter availability as treatment guidance for patients with anxious depression, IZKF


2015 ECNP Fellowship Award 2015
2014 Travel award of the “The Max Planck Society – Weizmann Institute of Science Laboratory for Experimental Psychiatry and Behavioral Neurogenetics” to attend the EBPS meeting “Stress, PTSD and Psychiatric Disorders” 2014 at the Weizmann Institute, Israel
2012 Travel award of the GlaxoSmithKline Foundation to attend the annual meeting of the International College of Neuropsychopharmacology 2012 in Stockholm, Sweden
2011 Travel award of the Boehringer-Ingelheim-Stiftung to attend the annual meeting of the German Association of Neuropsychopharmacology and Pharmacopsychiatry (AGNP) 2012 in Munich, Germany
2011 Travel award of the European College of Neuropsychopharmacology (ECNP) to attend the ECNP annual meeting in Paris, France.
2010 Travel fellowship of the German Academic Exchange Service (DAAD) to attend the SOBP annual meeting in New Orleans, LA, USA
2009 Travel fellowship award of the Society of Biological Psychiatry, Vancouver, Canada
2008 Travel award of the International Society of Psychiatric Genetics for WCPG 2008 in Osaka
2008 Travel award to attend the ECNP Workshop on Neuropsychopharmacology as selected junior speaker, Nice, France

Membership in scientific societies:

  • Arbeitsgemeinschaft Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP)
  • European College of Neuropsychopharmacology (ECNP)
  • Federation of European Neuroscience Societies
  • German Association for Psychiatry, Psychotherapy and Psychosomatics (DGPPN)
  • German Society of Biological Psychiatry
  • German Society of Bipolar Disorder
  • International Society of Psychiatric Genetics
  • Society of Biological Psychiatry (SOBP)

Editorial Boards:

Annals of Depression and Anxiety
Austin Biomarkers & Diagnosis

Reviewer for Funding:

  • Health Research Board, Dublin, Irland
  • Geneva University Hospitals, Genf, Schweiz
  • The Dutch Organisation for Health Research and Development (ZonMw)

Ad hoc reviewer (selection): > 45 peer-reviewed journals

Biological Psychiatry
British Journal of Pharmacology
CNS Drugs
European Child & Adolescent Psychiatry
European Neuropsychopharmacology
JAMA Psychiatry
Journal of Affective Disorders
Journal of Clinical Psychopharmacology
Journal of Psychiatric Research
Neuroscience Letters
Pharmacogenetics and Genomics
Pharmacogenomics Journal
PLoS One
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Scientific Reports
Translational Psychiatry
World Journal of Biological Psychiatry

Selected Publications

  1. Menke, Arloth, Best, Namendorf, Gerlach, Czamara, Lucae, Dunlop, Mletzko Crowe, Garlow, Nemeroff, Ritchie, Craighead, Mayberg, Rex-Haffner, Binder, Uhr; “Time-dependent effects of dexamethasone plasma concentrations on glucocorticoid receptor challenge tests”. (2016) Psychoneuroendocrinology, 69:161-171.
  2. Arloth, Bogdan, Weber, Frishman, Menke, Wagner, Balsevich, Schmidt, Karbalai, Czamara, Altmann, Trumbach, Wurst, Mehta, Uhr, Klengel, Erhardt, Carey, Conley, Major Depressive Disorder Working Group of the Psychiatric Genomics C, Ruepp A, Muller-Myhsok B, Hariri AR, Binder EB, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium PGC. “Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders”. (2015) Neuron 86:1189-1202. 
  3. Menke, Arloth, Gerber, Rex-Haffner, Uhr, Holsboer, Binder, Holsboer-Trachsler, Beck; “Dexamethasone Stimulated Gene Expression in Peripheral Blood Indicates Glucocorticoid-Receptor Hypersensitivity in Job-Related Exhaustion”. (2014) Psychoneuroendocrinology, 44: 35-46. . 
  4. Menke, Binder; “Epigenetic alterations in depression and antidepressant treatment”. (2014) Dialogues in Clinical Neuroscience, 16: 395-404.
  5. Menke; “Exploring the Genetic Landscape of Depression”. (2014) Ann Depress Anxiety, 1(2): 2.
  6. Menke; “Biomarkers for Taxonomy of Neuropsychiatric Diseases”. (2014) Austin Biomark Diagn, 1(2): 2.
  7. Issler, Harmati, Paul, Maeno, Navon, Zwang, Gil, Mayberg, Dunlop, Menke, Awatramani, Binder, Deneris, Lowry, Chen; “microRNA 135 is essential for chronic stress resiliency, antidepressant efficacy and intact serotonergic activity”. (2014) Neuron, 83(2):344-60.
  8. Menke; “Gene Expression: Biomarker of Antidepressant Therapy?”. (2013) International Review of Psychiatry, 25(5):579-91.
  9. Menke, Klengel, Rubel, Brückl, Pfister, Lucae, Uhr, Holsboer, Binder; “Genetic variation in FKBP5 is associated with the extent of stress hormone system dysregulation in major depression”. (2013) Genes, Brain & Behavior, 12(3): 289-96.
  10. Menke, Arloth, Pütz, Weber, Klengel, Mehta, Gonik, Rex-Haffner, Rubel, Uhr, Lucae, Deussing, Müller-Myhsok, Holsboer, Binder; “Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients”. (2012) Neuropsychopharmacology, 37(6):1455-64.
  11. Menke, Domschke, Czamara, Klengel, Hennings, Lucae, Baune, Arolt, Müller-Myhsok, Holsboer, Binder; „Genome-wide association study of antidepressant treatment emergent suicidal ideation“. (2012) Neuropsychopharmacology, 37(3):797-807.
  12. Menke, Rex-Haffner, Klengel, Binder, Mehta; “Peripheral blood gene expression: it all boils down to the RNA collection tubes”. (2012) BMC Research Notes, 5:1.
  13. Menke, Klengel, Binder; “Epigenetics, depression and antidepressant treatment”. (2012) Current Pharmaceutical Design, 18, 5879-5889.
  14. Ganea, Menke, Schmidt, Lucae, Rammes, Liebl, Harbich, Sterlemann, Storch, Uhr, Holsboer, Binder, Sillaber, Müller; „Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response”. (2012) Translational Psychiatry, 2:e177.
  15. Klengel, Menke; „Neurobiology of Depression“. (2012) DHZ, 2:14-18.
  16. Menke, Sämann, Kloiber, Czamara, Lucae, Hennings, Heck, Kohli, Czisch, Müller-Myhsok, Holsboer, Binder; “Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypes”. (2011) Psychoneuroendocrinology, 37(4):565-75.
  17. Menke, Binder; “Genetics of Major Depression”. (2011) Psychotherapie, 16(2):247-264.
  18. Kohli, Lucae, Saemann, Schmidt, Demirkan, Hek, Roeske, Alexander, Salyakina, Ripke, Hoehn, Specht, Menke, Hennings, Heck, Wolf, Ising, Schreiber, Czisch, Müller, Uhr, Bettecken, Becker, Schramm, Rietschel, Maier, Bradley, Ressler, Nöthen, Cichon, Craig, Breen, Lewis, Hofman, Tiemeier, van Duijn, Holsboer, Müller-Myhsok, Binder; “The neuronal transporter gene SLC6A15 confers risk to major depression”. (2011) Neuron, 70(2): 252-265.
  19. Mehta, Gonik,  Klengel, Rex-Haffner, Menke, Rubel, Mercer, Pütz, Bradley, Holsboer,  Ressler, Müller-Myhsok, Binder; “Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies”. (2011) Archives of General Psychiatry, 68(9):901-10.
  20. Kohli, Salyakina, Pfennig, Lucae, Horstmann, Menke, Kloiber, Hennings, Bradley, Ressler, Uhr, Müller-Myhsok Holsboer, Binder; “Genetic variants in the neurotrophic receptor encoding gene NTRK2 are 2 associated with a life history of suicide attempts in depressed patients”. (2010) Archives of General Psychiatry, 67(4): 348-59.
  21. Mehta, Menke, Binder; „Gene Expression Studies in Major Depression“. (2009) Current Psychiatry Reports, 12: 135-144.
  22. Ising, Lucae, Binder, Bettecken, Uhr, Ripke, Kohli, Hennings, Horstmann, Kloiber, Menke, Bondy, Rupprecht, Domschke, Baune, Arolt, Rush, Holsboer & Müller-Myhsok; “A genome-wide association study points to multiple loci predicting treatment outcome in depression”. (2009) Archives of General Psychiatry, 66(9):966-975.
  23. Menke, Lucae, Kloiber, Horstmann, Bettecken, Uhr, Ripke, Ising, Müller-Myhsok, Holsboer & Binder; “Genetic markers within glutamate receptors are associated with antidepressant treatment emergent suicidal ideation”. (2008) American Journal of Psychiatry, 165:7,917-918.